Endocannabinoid, Autism, and CBD – establishing the relationship between autism disorder and the endocannabinoid system as a mental health issue. For many years, scientists have researched the use of CBD and other cannabinoids to treat the symptoms of autism. Additionally, they have looked into numerous connections that seem to exist between autism and other endocannabinoid system functions.
Even though the field is still developing, some crucial ideas have already been established. According to a review released in May 2021, cannabis and cannabinoids “have promising effects in the treatment of autism condition. This can be employed in the alleviation of certain symptoms as a therapeutic alternative.” Read more…
In a study in which male and female mice lacking the CB1 cannabinoids receptor were examined for their social behavior and communication. Two crucial aspects of autism spectrum disorder were documented in a paper published a month later in Autism Research (ASD). These “mutant” mice vocalized and behaved differently than typical control mice, according to researchers.
Our findings show that deletion of this receptor leads to a number of impairments in social behavior and communication. This happens throughout early development and in adulthood, supporting the significance of the endocannabinoid system in these ASD-core behavioral areas.
To the Neurotypical, CBDV
The striatum, which is a component of the basal ganglia, is crucial to development. Previous studies by UK- and US-based authors found that people with autism conditions experience different effects from CBD and CBDV.
The latest study strengthens that connection even further by focusing on functional connectivity. This is a metric for correlating brain activity that may be obtained by fMRI (fMRI). The authors say that abnormal functional connectivity in the striatum may be a factor in a number of ASD symptoms.
Establishing if modulation of functional connectivity in the striatum is connected to a significant alteration in symptoms. Meaning, future studies may move science one step closer to the actual world.
Endocannabinoid, Autism, and CBD | Bladder Cancer and CBC
The most prevalent malignancy in the urinary system is bladder urothelial carcinoma. It was the focus of Israeli researchers who sought to identify cannabis components and the combinations of compounds exhibiting cytotoxicity. The scientists discovered that the most active extract comprised CBC and THC after testing numerous cannabis extracts for cell toxicity. This was done using an assay and high-performance liquid chromatography.
Their findings show that CBC, THC, and CBD slowed cell migration causing cell death in urothelial cancer cells.
Endocannabinoid, Autism, and CBD | Uncommon Cannabis Compounds
Not only cannabis but other plants also contain beneficial cannabinoids. Researchers from India and Poland describe the presence of phytocannabinoids in a review article published in the journal Plants. These include compounds found in fungi (grifolic acid, cannabiorcichromenic acid), and liverworts (vittatin, lunularic acid). Besides, we have rhododendrons (daurichromenic acid, rhododaurichromenic acid), and flowering plants from the genera Glycy (amorfrutin, bibenzyl-CBG).
The scientists note that these cannabinoids are found in very little concentration in nature, are known to protect plants from diseases. Besides, they are eaten to help them cope with abiotic stresses like cold, heat, intense light, and UV radiation. And because these substances also possess additional medicinal, antibacterial, and antimicrobial qualities, they may be helpful in treating human illness.
The scientists suggest that a better comprehension of the natural synthesis of these compounds in plants. They offer insight into how these compounds might be duplicated and generated on a large enough scale for clinical usage.
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