Gut Microbiota And ECS – The Endocannabinoid System

Gut Microbiota And ECS – Endocannabinoid System work hand in hand while demonstrating that LPS is a strong stimulator of its production and intonation. Besides, researchers established that the Endocannabinoid System ECS can control gut permeability. Technical research demonstrates that THC and CBD support strong Microbiome. Many inhabitants of bacteria, fungi, protozoa, and viruses live inside everyone. The Microbiome has as many cells that encode 100 times more hereditary material than the genome. Up to 1,000 diverse genera of bacteria live in the gut.

With this information, we realize that the Microbiome plays an important part in human health. It influences both humor and metabolism. Therefore, gut microbiota plays a great function in human disease. Turbulence to this system also known as the gastrointestinal tract causes obesity, cancer, and neurodegenerative illness.

The Role of the Endocannabinoid System (ECS)

An image showing how the Endocannabinoid system worksHow it operates depends on the current scientific investigation. The important discoveries have been extensively revealed in trendy and mass media in recent years. However, there is a significant feature of the connection between human health and the Microbiome. This has not been noticed outside the obscure world of scientific journals: the role of the Endocannabinoid System (ECS).

Present thoughts suggest that the ECS functions as a link between bacteria and the body. This includes the brain transmitting signals to and from in a symbiotic and helpful relationship. However, chronic mutilation of the Gut Microbiome damages bodily and psychological health.

Basically, humans and other animals control the “bugs” in their gut mainly using their diet. This includes the ingestion of Probiotic foods that enhance the healthy Microbiome. These bugs, therefore, break down food while making nutrients more accessible to the body. They offer them nourishment and assist in extracting as many nutrients as possible from food in the digestive tract.

Revolutionary research has revealed that we also influence our gut Microbiome. This was achieved not only through workouts and drugs but also through the use of cannabis. All these happen through the ordinary route of the ECS.

Gut Microbiota And ECS | Cannabis for Health of the Gut

An image of Cannabis for Health of the GutCommunications involving gut Microbiota and the Endocannabinoid system were initially discovered in 2010. A Belgian research team demonstrated that changing the gut Microbiome of fat mice using Probiotics altered ECS appearance in tissue. This implied that there was lipid metabolism as well as fat cell configuration.

In 2015 when researchers in Canada gave a daily routine of   Tetrahydrocannabinol to mice maintained on a high-fat diet. Gut Microbiome health such animals got better after 3 to 4 weeks resembling that of animals given a balanced diet. Read More

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The ECS acts as a link between bacteria and the body. This includes the brain, sending signals to and fro in a symbiotic, equally beneficial relationship.

Few studies have examined the effects of cannabis use on the human gut Microbiome. In 2017, researchers established important disparities among 19-lifetime consumers and 20 non-consumers. Cannabis users had bacteria quantity linked to a higher intake of calories but lesser BMI.

In 2018, researchers utilized archived anal swabs to evaluate the Microbiome of HIV-positive persons. They established that cannabis use was linked to the reduced abundance of two strains of bacteria associated with obesity.

Scientists are trying to appreciate the details. However, proof indicates that the Endocannabinoid system interrelates directly and bidirectional with bacteria in the gut. This influences the movement and structure of the Microbiome and helps pass its information to the body and brain. Microbiome health can be customized and even enhanced through plant cannabinoids (THC and CBD). Besides, it is enhanced through the body’s own Endocannabinoid, anandamide, and 2-AG. The production is inspired by exercise and eating specific foods.

Gut Microbiota And ECS | Pioneer Study

An image of lab technician at work - Gut Microbiota - Pioneer Study

The same way the structure of the Microbiome depends on more than a diet; our gut bacteria do beyond breaking down food. Besides, they control the epithelial obstruction, a vital protecting layer lining in the gastrointestinal tract.

According to Sharkey a researcher at the University of Calgary, epithelial obstruction plays an important role in sustaining general health. Besides, he served as senior author of the aforesaid 2015 study in which THC was given to mice.

The epithelial barrier is extremely critical to sustaining homeostasis, or the ordinary function of the body. According to Sharkey, the management of that fine coating is very cautiously administered by the body. They developed a complex management system to prevent damage and stop additional body erosion. The guts bacteria add value to the system as ECS is an important management element.

Sharkey is presently leading research to validate whether CB1 receptors assist the sharp rule of epithelial obstruction purpose. Even though he is not investigating simultaneous changes to the Microbiome, there’s a connection when gut bacteria interacts with the barrier. That’s why we live in a mutuality symbiotic relationship, says Sharkey.

Gut Microbiota And ECS | Targeting Microbiome

The ECS corresponds to both the gut barrier and the Microbiome whose wellbeing is crucial to human health. Besides, you can control the ECS using diet, workout, and cannabis-extracted compounds. Nevertheless, there are other ways to target the Microbiome through the ECS in order to attain precise health results.

It is a question the pharmaceutical industry has been vigorously exploring, says Cris Silvestri, a professor at Laval University in Quebec. He is also the Chair on the Gut Microbiome-Endocannabinoid System as an Integrator of Extreme Environmental Influences on Bioenergetics). Although no drugs have been produced for this rationale, the swift-growing field could start generating answers within five years. Hence, pointing directly to Probiotics that can be utilized in tweaking the gut Microbiome through the ECS.

Revolutionary research has revealed that our gut microbiome is influenced by diet, workout, medicine, and taking cannabinoids.

Receptors, Enzymes, And Lipid Intermediaries Linked To ECS

An image showing how receptors workOn the other hand, Silvestri is also implicated in two other studies that will give more information on this compound relationship. One is examining the influence on the Gut Microbiome of hereditary modulation of the ECS. This boosts 2-AG levels while suppressing CB1 action in treated mice. Besides, it adds value to research published in January 2020 by the same team showing that experimentally restricted change of the gut Microbiome. It causes vital alterations to gene appearance while signaling the Endocannabinoidome. This is an extensive system of enzymes, receptors, and lipid intermediaries linked to the ECS.

The other existing study examines ECS levels in the brains of purported germ-free mice, without Microbiome, and connected influence on behavior and anxiety. Besides, it assesses the impact on both after taking a Microbiome through a fecal Microbiota transplant.

According to Silvestri, there is hope that there will be therapeutic applications in the end. The drive emanates from being able to harvest the functionality of these bugs in the future to enhance human health.

Gut Microbiota And ECS | THC, and COVID-19

An image of COVID-19

A cannabinoids science lab headed by Prakash Nagarkatti at the University of South Carolina is also researching the gut Microbiome. It established an indication for treating one of the most detrimental impediments of COVID-19 in a number of patients. Read more about cannabinoids!

In November 2020 an investigation published in Frontiers in Pharmacology confirmed that THC infected mice had severe respiratory distress syndrome. This affects the deserted immune response called a cytokine storm that happens in a small proportion of COVID-19 patients.

THC changes the Microbiome in the gut to control irritation because THC bacteria produce short-chain fatty acids that restrain irritation. According to Nagarkatti, Staphylococcal Enterotoxin B was injected into the mice and it died within 4 to 5 days. This was because of cytokine storm and ARDS in the lungs. It was established that if you offer THC, it cures the mice. Read more

Nagarkatti doesn’t understand precisely how it takes place, but he understands it involves the Microbiome. They discovered that THC was shifting the gut Microbiome, as well as the lungs Microbiome. Besides, there were comparable transformations in the gut and lungs. When the fecal material was transplanted from cannabinoids injected mice to ordinary mice, they developed more resistance to ARDS.

This was confirmed in mice and is consequently not directly transferable to COVID-19 in humans. This is the first proof that cannabinoids’ change of the gut microbiome plays a role in restraining systemic irritation.


Publications About the ECS and the Microbiome

Papers published in 2019 on ECS and Microbiome, it was established that mixing THC and CBD change gut Microbiome in mice. This was achieved by reducing irritation with helpful implications for autoimmune illness.

Restraining irritation in the colon is very important for averting any kind of disease. This is because presently irritation is believed to be the fundamental cause of all things. This includes not only autoimmune illness but also cardiovascular and neurodegenerative illness, obesity, cancer, COVID-19.

According to Nagarkatti, while the molecular system requires development, the ECS plays a key role in adjusting irritation through gut Microbiota. THC changes the Microbiome in a manner that is helpful in restraining irritation. This is because microorganisms that are favored by THC or cannabinoids produce short-chain fatty acids that restrain irritation. Read more